相互作用
Atracurium + Betamethasone
重症度: 中等度
Atracurium and Betamethasone: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Corticosteroids given with non-depolarizing neuromuscular blockers, particularly during prolonged ICU use, have been associated with acute quadriplegic myopathy and prolonged muscle weakness. This can delay recovery and weaning from ventilation.
この相互作用をわかりやすく説明すると
Atracurium and Betamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Betamethasone belongs to Endocrine.
なぜ起こるのか
Combined effects on muscle fiber integrity and neuromuscular function leading to myopathy; the exact mechanism is not fully established.
対処法
Keep the duration of neuromuscular blockade and steroid exposure as short as possible and monitor neuromuscular function. Assess for persistent weakness and consider creatine kinase if myopathy is suspected.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtracuriumとBetamethasoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Atracuriumのその他の相互作用
Betamethasoneのその他の相互作用
よくある質問
Can I take Atracurium with Betamethasone?
MediHelp rates the interaction as moderate. Atracurium and Betamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with non-depolarizing neuromuscular blockers, particularly during prolonged ICU use, have been associated with acute quadriplegic myopathy and prolonged muscle weakness. This can delay recovery and weaning from ventilation.
How serious is the interaction between Atracurium and Betamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the duration of neuromuscular blockade and steroid exposure as short as possible and monitor neuromuscular function. Assess for persistent weakness and consider creatine kinase if myopathy is suspected.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
