相互作用
Certolizumab pegol + Natalizumab
重症度: 重大
Certolizumab pegol and Natalizumab: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Natalizumab with TNF blockers increases the risk of infection, and natalizumab labeling cautions against use with immunosuppressants and TNF inhibitors. Progressive multifocal leukoencephalopathy risk is a particular concern.
この相互作用をわかりやすく説明すると
Certolizumab pegol and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Certolizumab pegol belongs to Musculoskeletal; Natalizumab belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive immunosuppression from TNF-alpha blockade and alpha4-integrin inhibition limiting leukocyte trafficking.
対処法
Avoid concurrent use; separate therapies by appropriate washout. Monitor for infection and new neurological symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Certolizumab pegolとNatalizumabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Certolizumab pegolのその他の相互作用
- Adenovirus types 4 and 7 live + Certolizumab pegol 併用禁忌
- Bcg intravesical live + Certolizumab pegol 併用禁忌
- Bcg vaccine live + Certolizumab pegol 併用禁忌
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Certolizumab pegol + Measles mumps and rubella vaccine 併用禁忌
- Certolizumab pegol + Measles mumps and rubella vaccine live 併用禁忌
Natalizumabのその他の相互作用
よくある質問
Can I take Certolizumab pegol with Natalizumab?
MediHelp rates the interaction as major. Certolizumab pegol and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Natalizumab with TNF blockers increases the risk of infection, and natalizumab labeling cautions against use with immunosuppressants and TNF inhibitors. Progressive multifocal leukoencephalopathy risk is a particular concern.
How serious is the interaction between Certolizumab pegol and Natalizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; separate therapies by appropriate washout. Monitor for infection and new neurological symptoms.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
