相互作用
Chlorpromazine + Levodopa
重症度: 重大
Chlorpromazine and Levodopa: major interaction.
最終更新日
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概要
Chlorpromazine blocks dopamine D2 receptors and so opposes the effect of levodopa, which can worsen parkinsonian symptoms. Levodopa may also be less effective in controlling motor function.
この相互作用をわかりやすく説明すると
Chlorpromazine and Levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism: D2 receptor blockade counteracts dopamine replacement.
対処法
Avoid chlorpromazine in patients with Parkinson disease. If an antipsychotic is needed, use quetiapine or clozapine, or pimavanserin where appropriate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorpromazineとLevodopaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlorpromazineのその他の相互作用
Levodopaのその他の相互作用
よくある質問
Can I take Chlorpromazine with Levodopa?
MediHelp rates the interaction as major. Chlorpromazine and Levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine blocks dopamine D2 receptors and so opposes the effect of levodopa, which can worsen parkinsonian symptoms. Levodopa may also be less effective in controlling motor function.
How serious is the interaction between Chlorpromazine and Levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chlorpromazine in patients with Parkinson disease. If an antipsychotic is needed, use quetiapine or clozapine, or pimavanserin where appropriate.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
