相互作用
Isocarboxazid + Levodopa
重症度: 併用禁忌
Isocarboxazid and Levodopa: contraindicated interaction.
最終更新日
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概要
Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.
この相互作用をわかりやすく説明すると
Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
なぜ起こるのか
Nonselective MAO inhibition prevents breakdown of dopamine and norepinephrine formed from levodopa, producing excessive adrenergic stimulation.
対処法
Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、IsocarboxazidとLevodopaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isocarboxazidのその他の相互作用
Levodopaのその他の相互作用
よくある質問
Can I take Isocarboxazid with Levodopa?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.
How serious is the interaction between Isocarboxazid and Levodopa?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
