相互作用
Amisulpride + Levodopa
重症度: 重大
Amisulpride and Levodopa: major interaction.
最終更新日
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概要
Amisulpride blocks dopamine receptors and can counteract the effect of levodopa, worsening parkinsonian symptoms. Levodopa may in turn aggravate psychosis and reduce the antipsychotic effect.
この相互作用をわかりやすく説明すると
Amisulpride and Levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism at central D2/D3 dopamine receptors.
対処法
Avoid the combination. In Parkinson's disease psychosis use an antipsychotic with low D2 affinity such as quetiapine or clozapine instead.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、AmisulprideとLevodopaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amisulprideのその他の相互作用
Levodopaのその他の相互作用
よくある質問
Can I take Amisulpride with Levodopa?
MediHelp rates the interaction as major. Amisulpride and Levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride blocks dopamine receptors and can counteract the effect of levodopa, worsening parkinsonian symptoms. Levodopa may in turn aggravate psychosis and reduce the antipsychotic effect.
How serious is the interaction between Amisulpride and Levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. In Parkinson's disease psychosis use an antipsychotic with low D2 affinity such as quetiapine or clozapine instead.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
