相互作用
Chlorpropamide + Sulphasalazine
重症度: 中等度
Chlorpropamide and Sulphasalazine: moderate interaction.
最終更新日
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概要
Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
この相互作用をわかりやすく説明すると
Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
なぜ起こるのか
Possible displacement from plasma protein binding and/or reduced sulfonylurea clearance; the mechanism is not well established for sulfasalazine.
対処法
Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorpropamideとSulphasalazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sulphasalazineのその他の相互作用
Chlorpropamideのその他の相互作用
よくある質問
Can I take Chlorpropamide with Sulphasalazine?
MediHelp rates the interaction as moderate. Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
How serious is the interaction between Chlorpropamide and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
