相互作用
Cholecalciferol + Digoxin
重症度: 重大
Cholecalciferol and Digoxin: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Vitamin D-induced hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. The risk is greatest with high-dose vitamin D or active analogs.
この相互作用をわかりやすく説明すると
Cholecalciferol and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholecalciferol belongs to Musculoskeletal; Digoxin belongs to Cardiovascular.
なぜ起こるのか
Hypercalcemia augments digoxin's cardiac effects, increasing digoxin toxicity risk.
対処法
Monitor serum calcium and digoxin toxicity signs, and keep vitamin D doses modest; adjust therapy if calcium rises.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CholecalciferolとDigoxinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cholecalciferolのその他の相互作用
Digoxinのその他の相互作用
よくある質問
Can I take Cholecalciferol with Digoxin?
MediHelp rates the interaction as major. Cholecalciferol and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin D-induced hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. The risk is greatest with high-dose vitamin D or active analogs.
How serious is the interaction between Cholecalciferol and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and digoxin toxicity signs, and keep vitamin D doses modest; adjust therapy if calcium rises.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium Carbonate. The full list is on the Cholecalciferol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
