相互作用
Calcium Carbonate + Cholecalciferol
重症度: 中等度
Calcium Carbonate and Cholecalciferol: moderate interaction.
最終更新日
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概要
Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
この相互作用をわかりやすく説明すると
Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium Carbonate belongs to Gastrointestinal Tract; Cholecalciferol belongs to Musculoskeletal.
なぜ起こるのか
Pharmacodynamic: cholecalciferol, via calcitriol, enhances active intestinal calcium absorption, adding to the calcium supplied by calcium carbonate.
対処法
Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Calcium CarbonateとCholecalciferolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Calcium carbonate and cholecalciferol chewable tablets SmPC - Special Warnings and Interactions — EMA SmPC
Calcium Carbonateのその他の相互作用
Cholecalciferolのその他の相互作用
よくある質問
Can I take Calcium Carbonate with Cholecalciferol?
MediHelp rates the interaction as moderate. Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
How serious is the interaction between Calcium Carbonate and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
What other medicines interact with Calcium Carbonate?
MediHelp also lists interactions of Calcium Carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium Carbonate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
