相互作用
Cilostazol + Ticlopidine
重症度: 重大
Cilostazol and Ticlopidine: major interaction.
最終更新日
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概要
Ticlopidine inhibits CYP2C19 and raises exposure to cilostazol's active metabolites, increasing risks such as headache, tachycardia and bleeding. Both drugs impair platelet function, adding to bleeding risk.
この相互作用をわかりやすく説明すると
Cilostazol and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cilostazol belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
なぜ起こるのか
CYP2C19 inhibition reduces cilostazol metabolism, plus additive antiplatelet effects.
対処法
Reduce the cilostazol dose to 50 mg twice daily per labeling when given with strong CYP2C19 inhibitors. Monitor for bleeding, palpitations and headache.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CilostazolとTiclopidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ticlopidineのその他の相互作用
Cilostazolのその他の相互作用
よくある質問
Can I take Cilostazol with Ticlopidine?
MediHelp rates the interaction as major. Cilostazol and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits CYP2C19 and raises exposure to cilostazol's active metabolites, increasing risks such as headache, tachycardia and bleeding. Both drugs impair platelet function, adding to bleeding risk.
How serious is the interaction between Cilostazol and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cilostazol dose to 50 mg twice daily per labeling when given with strong CYP2C19 inhibitors. Monitor for bleeding, palpitations and headache.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
