相互作用
Clarithromycin + Eliglustat
重症度: 併用禁忌
Clarithromycin and Eliglustat: contraindicated interaction.
最終更新日
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概要
Clarithromycin strongly inhibits CYP3A4 and can substantially raise eliglustat exposure, which is associated with PR, QRS and QT interval prolongation and arrhythmia. The risk is highest in CYP2D6 poor or intermediate metabolizers and when CYP2D6 is also inhibited.
この相互作用をわかりやすく説明すると
Clarithromycin and Eliglustat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Eliglustat belongs to Miscellaneous.
なぜ起こるのか
Clarithromycin inhibits CYP3A4, a key metabolic pathway for eliglustat, increasing its plasma concentration.
対処法
Avoid in CYP2D6 intermediate or poor metabolizers and in patients on CYP2D6 inhibitors; otherwise use a different antibiotic or reduce eliglustat dose per labeling with ECG monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、ClarithromycinとEliglustatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Eliglustatのその他の相互作用
よくある質問
Can I take Clarithromycin with Eliglustat?
MediHelp rates the interaction as contraindicated. Clarithromycin and Eliglustat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin strongly inhibits CYP3A4 and can substantially raise eliglustat exposure, which is associated with PR, QRS and QT interval prolongation and arrhythmia. The risk is highest in CYP2D6 poor or intermediate metabolizers and when CYP2D6 is also inhibited.
How serious is the interaction between Clarithromycin and Eliglustat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 intermediate or poor metabolizers and in patients on CYP2D6 inhibitors; otherwise use a different antibiotic or reduce eliglustat dose per labeling with ECG monitoring.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
