相互作用
Eliglustat + Itraconazole
重症度: 併用禁忌
Eliglustat and Itraconazole: contraindicated interaction.
最終更新日
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概要
Itraconazole strongly increases eliglustat exposure, and both can prolong the QT interval. This raises the risk of cardiac conduction abnormalities and arrhythmia.
この相互作用をわかりやすく説明すると
Eliglustat and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
なぜ起こるのか
Strong CYP3A4 inhibition raises eliglustat levels, with additive QT prolongation.
対処法
Avoid the combination, and especially so in CYP2D6 poor or intermediate metabolizers. Consider an alternative antifungal.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、EliglustatとItraconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Itraconazoleのその他の相互作用
Eliglustatのその他の相互作用
よくある質問
Can I take Eliglustat with Itraconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole strongly increases eliglustat exposure, and both can prolong the QT interval. This raises the risk of cardiac conduction abnormalities and arrhythmia.
How serious is the interaction between Eliglustat and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and especially so in CYP2D6 poor or intermediate metabolizers. Consider an alternative antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
