相互作用
Eliglustat + Pimozide
重症度: 併用禁忌
Eliglustat and Pimozide: contraindicated interaction.
最終更新日
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概要
Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and pimozide is a potent QT-prolonging drug. Eliglustat is also a CYP2D6 inhibitor and a CYP3A4 substrate, which may further raise pimozide exposure.
この相互作用をわかりやすく説明すると
Eliglustat and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Pimozide belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation plus CYP2D6 inhibition reducing pimozide clearance.
対処法
Avoid the combination. Choose alternative therapy for either condition.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EliglustatとPimozideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pimozideのその他の相互作用
Eliglustatのその他の相互作用
よくある質問
Can I take Eliglustat with Pimozide?
MediHelp rates the interaction as contraindicated. Eliglustat and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and pimozide is a potent QT-prolonging drug. Eliglustat is also a CYP2D6 inhibitor and a CYP3A4 substrate, which may further raise pimozide exposure.
How serious is the interaction between Eliglustat and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose alternative therapy for either condition.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
