相互作用
Eliglustat + Ketoconazole
重症度: 併用禁忌
Eliglustat and Ketoconazole: contraindicated interaction.
最終更新日
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概要
Ketoconazole substantially increases eliglustat exposure, which can prolong the PR, QTc and QRS intervals and cause arrhythmias. Labeling contraindicates or restricts the combination depending on CYP2D6 metabolizer status.
この相互作用をわかりやすく説明すると
Eliglustat and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Ketoconazole belongs to Anti Fungals.
なぜ起こるのか
Ketoconazole inhibits CYP3A4 and, to a lesser extent, CYP2D6, the two main pathways for eliglustat clearance.
対処法
Avoid in intermediate and poor CYP2D6 metabolizers and when combined with a CYP2D6 inhibitor. In extensive metabolizers, eliglustat dose reduction is required, with ECG monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、EliglustatとKetoconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ketoconazoleのその他の相互作用
Eliglustatのその他の相互作用
よくある質問
Can I take Eliglustat with Ketoconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole substantially increases eliglustat exposure, which can prolong the PR, QTc and QRS intervals and cause arrhythmias. Labeling contraindicates or restricts the combination depending on CYP2D6 metabolizer status.
How serious is the interaction between Eliglustat and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in intermediate and poor CYP2D6 metabolizers and when combined with a CYP2D6 inhibitor. In extensive metabolizers, eliglustat dose reduction is required, with ECG monitoring.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
