相互作用
Eliglustat + Posaconazole
重症度: 併用禁忌
Eliglustat and Posaconazole: contraindicated interaction.
最終更新日
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概要
Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.
この相互作用をわかりやすく説明すると
Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
なぜ起こるのか
Posaconazole inhibits CYP3A4, a secondary eliglustat clearance pathway that becomes critical when CYP2D6 activity is low or inhibited.
対処法
Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EliglustatとPosaconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Posaconazoleのその他の相互作用
Eliglustatのその他の相互作用
よくある質問
Can I take Eliglustat with Posaconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.
How serious is the interaction between Eliglustat and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
