相互作用
Clotrimazole + Cyclosporine
重症度: 中等度
Clotrimazole and Cyclosporine: moderate interaction.
最終更新日
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概要
Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
この相互作用をわかりやすく説明すると
Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Clotrimazole may inhibit CYP3A4 and P-glycoprotein, reducing cyclosporine clearance.
対処法
Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClotrimazoleとCyclosporineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clotrimazoleのその他の相互作用
よくある質問
Can I take Clotrimazole with Cyclosporine?
MediHelp rates the interaction as moderate. Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
How serious is the interaction between Clotrimazole and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
