相互作用
Bosutinib + Clotrimazole
重症度: 中等度
Bosutinib and Clotrimazole: moderate interaction.
最終更新日
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概要
Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
この相互作用をわかりやすく説明すると
Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Clotrimazole belongs to Anti Fungals.
なぜ起こるのか
Clotrimazole is a CYP3A4 inhibitor that may reduce bosutinib metabolism.
対処法
Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosutinibとClotrimazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clotrimazoleのその他の相互作用
Bosutinibのその他の相互作用
よくある質問
Can I take Bosutinib with Clotrimazole?
MediHelp rates the interaction as moderate. Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
