相互作用
Clotrimazole + Mavacamten
重症度: 重大
Clotrimazole and Mavacamten: major interaction.
最終更新日
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概要
Clotrimazole with systemic exposure may inhibit CYP2C19 and CYP3A4, increasing mavacamten levels. Excess exposure can reduce left ventricular ejection fraction and cause heart failure.
この相互作用をわかりやすく説明すると
Clotrimazole and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clotrimazole belongs to Anti Fungals; Mavacamten belongs to Cardiovascular.
なぜ起こるのか
Inhibition of CYP2C19 and CYP3A4 metabolism of mavacamten.
対処法
Avoid or closely monitor with echocardiographic assessment of LVEF when systemic clotrimazole is started. Adjust mavacamten dose per labeling.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClotrimazoleとMavacamtenの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clotrimazoleのその他の相互作用
Mavacamtenのその他の相互作用
よくある質問
Can I take Clotrimazole with Mavacamten?
MediHelp rates the interaction as major. Clotrimazole and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clotrimazole with systemic exposure may inhibit CYP2C19 and CYP3A4, increasing mavacamten levels. Excess exposure can reduce left ventricular ejection fraction and cause heart failure.
How serious is the interaction between Clotrimazole and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or closely monitor with echocardiographic assessment of LVEF when systemic clotrimazole is started. Adjust mavacamten dose per labeling.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mobocertinib, Voclosporin. The full list is on the Clotrimazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
