相互作用
Clotrimazole + Voclosporin
重症度: 重大
Clotrimazole and Voclosporin: major interaction.
最終更新日
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概要
Systemic clotrimazole may inhibit CYP3A4 and increase voclosporin exposure. This raises the risk of nephrotoxicity, hypertension, hyperkalemia and over-immunosuppression.
この相互作用をわかりやすく説明すると
Clotrimazole and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clotrimazole belongs to Anti Fungals; Voclosporin belongs to Miscellaneous.
なぜ起こるのか
Inhibition of CYP3A4-mediated metabolism of voclosporin.
対処法
Reduce the voclosporin dose per labeling for moderate CYP3A4 inhibitors and monitor renal function, potassium and blood pressure.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClotrimazoleとVoclosporinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clotrimazoleのその他の相互作用
Voclosporinのその他の相互作用
よくある質問
Can I take Clotrimazole with Voclosporin?
MediHelp rates the interaction as major. Clotrimazole and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic clotrimazole may inhibit CYP3A4 and increase voclosporin exposure. This raises the risk of nephrotoxicity, hypertension, hyperkalemia and over-immunosuppression.
How serious is the interaction between Clotrimazole and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the voclosporin dose per labeling for moderate CYP3A4 inhibitors and monitor renal function, potassium and blood pressure.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
