相互作用
Cannabidiol + Clotrimazole
重症度: 中等度
Cannabidiol and Clotrimazole: moderate interaction.
最終更新日
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概要
Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
この相互作用をわかりやすく説明すると
Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clotrimazole belongs to Anti Fungals.
なぜ起こるのか
Inhibition of CYP3A4-mediated metabolism of cannabidiol by clotrimazole.
対処法
Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CannabidiolとClotrimazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clotrimazoleのその他の相互作用
Cannabidiolのその他の相互作用
よくある質問
Can I take Cannabidiol with Clotrimazole?
MediHelp rates the interaction as moderate. Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
How serious is the interaction between Cannabidiol and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
