相互作用
Clozapine + Dicyclomine
重症度: 重大
Clozapine and Dicyclomine: major interaction.
最終更新日
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概要
Clozapine is strongly anticholinergic and already causes severe constipation and gastrointestinal hypomotility. Adding dicyclomine raises the risk of serious constipation, ileus, urinary retention, tachycardia and delirium.
この相互作用をわかりやすく説明すると
Clozapine and Dicyclomine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
なぜ起こるのか
Additive muscarinic receptor blockade leading to reduced gastrointestinal motility and other anticholinergic effects.
対処法
Avoid the combination where possible; if used, monitor bowel function closely, treat constipation early, and reassess the need for dicyclomine.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClozapineとDicyclomineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dicyclomineのその他の相互作用
Clozapineのその他の相互作用
よくある質問
Can I take Clozapine with Dicyclomine?
MediHelp rates the interaction as major. Clozapine and Dicyclomine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly anticholinergic and already causes severe constipation and gastrointestinal hypomotility. Adding dicyclomine raises the risk of serious constipation, ileus, urinary retention, tachycardia and delirium.
How serious is the interaction between Clozapine and Dicyclomine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor bowel function closely, treat constipation early, and reassess the need for dicyclomine.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Henbane, Imipramine, Pramlintide. The full list is on the Dicyclomine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
