相互作用
Dicyclomine + Imipramine
重症度: 重大
Dicyclomine and Imipramine: major interaction.
最終更新日
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概要
Imipramine has marked anticholinergic activity, so combined use adds to the anticholinergic burden. This can produce severe constipation, ileus, urinary retention, tachycardia, blurred vision, delirium and heat intolerance.
この相互作用をわかりやすく説明すると
Dicyclomine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dicyclomine belongs to Respiratory; Imipramine belongs to Central Nervous System.
なぜ起こるのか
Additive antimuscarinic pharmacodynamic effects.
対処法
Avoid the combination if possible, particularly in older adults. If used, monitor for ileus, urinary retention, confusion and tachycardia and reduce doses as needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DicyclomineとImipramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dicyclomineのその他の相互作用
Imipramineのその他の相互作用
よくある質問
Can I take Dicyclomine with Imipramine?
MediHelp rates the interaction as major. Dicyclomine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imipramine has marked anticholinergic activity, so combined use adds to the anticholinergic burden. This can produce severe constipation, ileus, urinary retention, tachycardia, blurred vision, delirium and heat intolerance.
How serious is the interaction between Dicyclomine and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, particularly in older adults. If used, monitor for ileus, urinary retention, confusion and tachycardia and reduce doses as needed.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Pramlintide. The full list is on the Dicyclomine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
