相互作用
Conivaptan + Red yeast rice
重症度: 重大
Conivaptan and Red yeast rice: major interaction.
最終更新日
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概要
Red yeast rice supplies monacolin K, identical to lovastatin, which relies on CYP3A4 for clearance. Conivaptan is a potent CYP3A4 inhibitor, so monacolin K levels may rise and increase the risk of myopathy.
この相互作用をわかりやすく説明すると
Conivaptan and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Conivaptan inhibits CYP3A4, decreasing monacolin K metabolism.
対処法
Avoid the combination and withhold red yeast rice during conivaptan therapy. Monitor for muscle symptoms and creatine kinase if exposure occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ConivaptanとRed yeast riceの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Red yeast riceのその他の相互作用
よくある質問
Can I take Conivaptan with Red yeast rice?
MediHelp rates the interaction as major. Conivaptan and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice supplies monacolin K, identical to lovastatin, which relies on CYP3A4 for clearance. Conivaptan is a potent CYP3A4 inhibitor, so monacolin K levels may rise and increase the risk of myopathy.
How serious is the interaction between Conivaptan and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and withhold red yeast rice during conivaptan therapy. Monitor for muscle symptoms and creatine kinase if exposure occurs.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
