相互作用
Atazanavir + Red yeast rice
重症度: 重大
Atazanavir and Red yeast rice: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Red yeast rice contains monacolin K, which is chemically identical to lovastatin, a CYP3A4 substrate. Atazanavir, boosted or not, is a strong CYP3A4 inhibitor and can greatly increase monacolin K exposure, raising the risk of myopathy and rhabdomyolysis.
この相互作用をわかりやすく説明すると
Atazanavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Red yeast rice belongs to Gastrointestinal Tract.
なぜ起こるのか
Atazanavir inhibits CYP3A4, reducing first-pass and systemic clearance of monacolin K (lovastatin).
対処法
Avoid the combination and use a statin with a lower CYP3A4 dependence, such as pravastatin or rosuvastatin, at a suitable dose. Counsel the patient to report muscle pain or dark urine.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとRed yeast riceの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Red yeast riceのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Red yeast rice?
MediHelp rates the interaction as major. Atazanavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, which is chemically identical to lovastatin, a CYP3A4 substrate. Atazanavir, boosted or not, is a strong CYP3A4 inhibitor and can greatly increase monacolin K exposure, raising the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Atazanavir and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a statin with a lower CYP3A4 dependence, such as pravastatin or rosuvastatin, at a suitable dose. Counsel the patient to report muscle pain or dark urine.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
