相互作用
Red yeast rice + Tipranavir
重症度: 併用禁忌
Red yeast rice and Tipranavir: contraindicated interaction.
最終更新日
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概要
Red yeast rice contains monacolin K, identical to lovastatin, a CYP3A4 substrate. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may substantially raise monacolin K levels, increasing the risk of muscle toxicity and rhabdomyolysis.
この相互作用をわかりやすく説明すると
Red yeast rice and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Red yeast rice belongs to Gastrointestinal Tract; Tipranavir belongs to Anti Virals.
なぜ起こるのか
Ritonavir-boosted tipranavir inhibits CYP3A4, increasing monacolin K (lovastatin) exposure.
対処法
Avoid red yeast rice during tipranavir therapy. If a statin is needed, select one not reliant on CYP3A4 and monitor for muscle symptoms.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Red yeast riceとTipranavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Red yeast riceのその他の相互作用
Tipranavirのその他の相互作用
よくある質問
Can I take Red yeast rice with Tipranavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, a CYP3A4 substrate. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may substantially raise monacolin K levels, increasing the risk of muscle toxicity and rhabdomyolysis.
How serious is the interaction between Red yeast rice and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice during tipranavir therapy. If a statin is needed, select one not reliant on CYP3A4 and monitor for muscle symptoms.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Atazanavir. The full list is on the Red yeast rice page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
