相互作用
Red yeast rice + Saquinavir
重症度: 併用禁忌
Red yeast rice and Saquinavir: contraindicated interaction.
最終更新日
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概要
Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
この相互作用をわかりやすく説明すると
Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Saquinavir (with ritonavir boosting) inhibits CYP3A4, increasing monacolin K (lovastatin) exposure.
対処法
Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Red yeast riceとSaquinavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Red yeast riceのその他の相互作用
よくある質問
Can I take Red yeast rice with Saquinavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
How serious is the interaction between Red yeast rice and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Tipranavir, Atazanavir. The full list is on the Red yeast rice page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
