相互作用
Red yeast rice + Ritonavir
重症度: 併用禁忌
Red yeast rice and Ritonavir: contraindicated interaction.
最終更新日
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概要
Red yeast rice contains monacolin K, identical to lovastatin, which is extensively metabolized by CYP3A4. Ritonavir is a potent CYP3A4 inhibitor and can greatly increase statin exposure, leading to myopathy and rhabdomyolysis.
この相互作用をわかりやすく説明すると
Red yeast rice and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Red yeast rice belongs to Gastrointestinal Tract; Ritonavir belongs to Anti Virals.
なぜ起こるのか
Ritonavir strongly inhibits CYP3A4 and markedly increases monacolin K (lovastatin) exposure.
対処法
Do not combine; stop red yeast rice while on ritonavir. Choose an alternative lipid-lowering agent such as pravastatin or rosuvastatin with dose limits per labeling.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Red yeast riceとRitonavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Red yeast riceのその他の相互作用
Ritonavirのその他の相互作用
よくある質問
Can I take Red yeast rice with Ritonavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, which is extensively metabolized by CYP3A4. Ritonavir is a potent CYP3A4 inhibitor and can greatly increase statin exposure, leading to myopathy and rhabdomyolysis.
How serious is the interaction between Red yeast rice and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop red yeast rice while on ritonavir. Choose an alternative lipid-lowering agent such as pravastatin or rosuvastatin with dose limits per labeling.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Saquinavir, Tipranavir, Atazanavir. The full list is on the Red yeast rice page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
