相互作用
Ibutilide + Levofloxacin
重症度: 併用禁忌
Ibutilide and Levofloxacin: contraindicated interaction.
最終更新日
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概要
Ibutilide is a class III antiarrhythmic with a substantial risk of torsades de pointes. Levofloxacin further prolongs repolarization, making a serious ventricular arrhythmia more likely.
この相互作用をわかりやすく説明すると
Ibutilide and Levofloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Levofloxacin belongs to Anti Bacterial.
なぜ起こるのか
Additive potassium channel blockade causing QT prolongation.
対処法
Avoid giving levofloxacin to patients receiving ibutilide and choose a non-QT-prolonging antibiotic. If ibutilide is being used for cardioversion, defer fluoroquinolone administration until after the procedure and monitoring period.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IbutilideとLevofloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Levofloxacinのその他の相互作用
Ibutilideのその他の相互作用
よくある質問
Can I take Ibutilide with Levofloxacin?
MediHelp rates the interaction as contraindicated. Ibutilide and Levofloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide is a class III antiarrhythmic with a substantial risk of torsades de pointes. Levofloxacin further prolongs repolarization, making a serious ventricular arrhythmia more likely.
How serious is the interaction between Ibutilide and Levofloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving levofloxacin to patients receiving ibutilide and choose a non-QT-prolonging antibiotic. If ibutilide is being used for cardioversion, defer fluoroquinolone administration until after the procedure and monitoring period.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Thioridazine, Vandetanib. The full list is on the Levofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
