相互作用
Levofloxacin + Thioridazine
重症度: 併用禁忌
Levofloxacin and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.
この相互作用をわかりやすく説明すると
Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levofloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive blockade of cardiac potassium channels causing marked delay in ventricular repolarization.
対処法
Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LevofloxacinとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Levofloxacinのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Levofloxacin with Thioridazine?
MediHelp rates the interaction as contraindicated. Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.
How serious is the interaction between Levofloxacin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Vandetanib. The full list is on the Levofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
