相互作用
Levofloxacin + Ziprasidone
重症度: 併用禁忌
Levofloxacin and Ziprasidone: contraindicated interaction.
最終更新日
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概要
Ziprasidone is known to prolong the QT interval, and its labeling advises against combination with other QT-prolonging drugs. Adding levofloxacin increases the risk of torsades de pointes and sudden cardiac death.
この相互作用をわかりやすく説明すると
Levofloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levofloxacin belongs to Anti Bacterial; Ziprasidone belongs to Central Nervous System.
なぜ起こるのか
Additive blockade of cardiac potassium channels delaying ventricular repolarization.
対処法
Avoid the combination and use a non-QT-prolonging antibiotic. If a fluoroquinolone is essential, consider an alternative antipsychotic or specialist advice with ECG monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LevofloxacinとZiprasidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Levofloxacinのその他の相互作用
Ziprasidoneのその他の相互作用
よくある質問
Can I take Levofloxacin with Ziprasidone?
MediHelp rates the interaction as contraindicated. Levofloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is known to prolong the QT interval, and its labeling advises against combination with other QT-prolonging drugs. Adding levofloxacin increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Levofloxacin and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. If a fluoroquinolone is essential, consider an alternative antipsychotic or specialist advice with ECG monitoring.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
