相互作用
Dexbrompheniramine + Fentanyl
重症度: 中等度
Dexbrompheniramine and Fentanyl: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Dexbrompheniramine is a sedating antihistamine that adds to fentanyl's CNS depression. The combination can cause marked drowsiness and impaired psychomotor function, and respiratory depression is possible with higher doses.
この相互作用をわかりやすく説明すると
Dexbrompheniramine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexbrompheniramine belongs to Respiratory; Fentanyl belongs to Musculoskeletal.
なぜ起こるのか
Additive CNS depression from an opioid and a sedating first-generation antihistamine.
対処法
Use the lowest effective doses and monitor for sedation and respiratory depression. Advise patients to avoid alcohol and driving.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DexbrompheniramineとFentanylの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Fentanylのその他の相互作用
Dexbrompheniramineのその他の相互作用
よくある質問
Can I take Dexbrompheniramine with Fentanyl?
MediHelp rates the interaction as moderate. Dexbrompheniramine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexbrompheniramine is a sedating antihistamine that adds to fentanyl's CNS depression. The combination can cause marked drowsiness and impaired psychomotor function, and respiratory depression is possible with higher doses.
How serious is the interaction between Dexbrompheniramine and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Advise patients to avoid alcohol and driving.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
