相互作用
Efavirenz + Erdafitinib
重症度: 重大
Efavirenz and Erdafitinib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Efavirenz has opposing effects on erdafitinib handling, so exposure is unpredictable. It may lower levels through CYP3A4 induction, risking loss of efficacy, or raise them via CYP2C9 effects, risking toxicity such as hyperphosphatemia and ocular events.
この相互作用をわかりやすく説明すると
Efavirenz and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Erdafitinib belongs to Oncology.
なぜ起こるのか
Efavirenz induces CYP3A4 and has variable effects on CYP2C9, both of which metabolize erdafitinib.
対処法
Prefer an alternative antiretroviral. If coadministered, monitor serum phosphate, ocular symptoms and tumour response and adjust the erdafitinib dose accordingly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EfavirenzとErdafitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Efavirenzのその他の相互作用
Erdafitinibのその他の相互作用
よくある質問
Can I take Efavirenz with Erdafitinib?
MediHelp rates the interaction as major. Efavirenz and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz has opposing effects on erdafitinib handling, so exposure is unpredictable. It may lower levels through CYP3A4 induction, risking loss of efficacy, or raise them via CYP2C9 effects, risking toxicity such as hyperphosphatemia and ocular events.
How serious is the interaction between Efavirenz and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiretroviral. If coadministered, monitor serum phosphate, ocular symptoms and tumour response and adjust the erdafitinib dose accordingly.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
