相互作用
Glycerol phenylbutyrate + Haloperidol
重症度: 中等度
Glycerol phenylbutyrate and Haloperidol: moderate interaction.
最終更新日
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概要
Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
この相互作用をわかりやすく説明すると
Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
なぜ起こるのか
Haloperidol may increase blood ammonia, opposing the nitrogen-scavenging effect of glycerol phenylbutyrate; the mechanism is not fully established.
対処法
Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Glycerol phenylbutyrateとHaloperidolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Haloperidolのその他の相互作用
Glycerol phenylbutyrateのその他の相互作用
よくある質問
Can I take Glycerol phenylbutyrate with Haloperidol?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
How serious is the interaction between Glycerol phenylbutyrate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
