相互作用
Hydroxyurea + Stavudine
重症度: 重大
Hydroxyurea and Stavudine: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
In HIV patients, hydroxyurea combined with stavudine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, sometimes fatal. The overlapping toxicities make the combination hazardous.
この相互作用をわかりやすく説明すると
Hydroxyurea and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyurea belongs to Miscellaneous; Stavudine belongs to Anti Virals.
なぜ起こるのか
Overlapping pancreatic, hepatic and neurotoxic effects; the precise mechanism is not fully established.
対処法
Avoid the combination and choose an antiretroviral without these overlapping toxicities. If it was used, stop and evaluate promptly for pancreatitis, liver injury or neuropathy.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、HydroxyureaとStavudineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Stavudineのその他の相互作用
Hydroxyureaのその他の相互作用
よくある質問
Can I take Hydroxyurea with Stavudine?
MediHelp rates the interaction as major. Hydroxyurea and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. In HIV patients, hydroxyurea combined with stavudine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, sometimes fatal. The overlapping toxicities make the combination hazardous.
How serious is the interaction between Hydroxyurea and Stavudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiretroviral without these overlapping toxicities. If it was used, stop and evaluate promptly for pancreatitis, liver injury or neuropathy.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Didanosine, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide. The full list is on the Stavudine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
