相互作用
Amiodarone + Levofloxacin
重症度: 重大
Amiodarone and Levofloxacin: major interaction.
最終更新日 出典: US FDA label
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概要
Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with bradycardia, hypokalemia, hypomagnesemia, structural heart disease, older age and female sex. Amiodarone's very long half-life means the risk persists for weeks after stopping.
この相互作用をわかりやすく説明すると
Amiodarone and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Levofloxacin belongs to Anti Bacterial.
なぜ起こるのか
Pharmacodynamic additive QT prolongation through blockade of the IKr (hERG) potassium current by both drugs.
対処法
Avoid the combination if possible and choose an antibiotic with less QT effect. If it must be used, obtain a baseline ECG and repeat it after starting, correct potassium and magnesium, and stop other QT-prolonging drugs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとLevofloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Levofloxacinのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Levofloxacin?
MediHelp rates the interaction as major. Amiodarone and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with bradycardia, hypokalemia, hypomagnesemia, structural heart disease, older age and female sex. Amiodarone's very long half-life means the risk persists for weeks after stopping.
How serious is the interaction between Amiodarone and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an antibiotic with less QT effect. If it must be used, obtain a baseline ECG and repeat it after starting, correct potassium and magnesium, and stop other QT-prolonging drugs.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
