相互作用
Ketorolac intranasal + Vitamin k1
重症度: 中等度
Ketorolac intranasal and Vitamin k1: moderate interaction.
最終更新日
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概要
Ketorolac inhibits platelet function and increases bleeding risk, which may work against the aim of phytonadione in bleeding or coagulopathy. Systemic exposure from the nasal form is lower than oral or injected ketorolac but still present.
この相互作用をわかりやすく説明すると
Ketorolac intranasal and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Ketorolac's reversible COX-1 inhibition impairs platelet aggregation, a pharmacodynamic effect not corrected by vitamin K.
対処法
Avoid ketorolac in patients with active bleeding or vitamin K-responsive coagulopathy; choose a non-NSAID analgesic.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ketorolac intranasalとVitamin k1の臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Vitamin k1のその他の相互作用
よくある質問
Can I take Ketorolac intranasal with Vitamin k1?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac inhibits platelet function and increases bleeding risk, which may work against the aim of phytonadione in bleeding or coagulopathy. Systemic exposure from the nasal form is lower than oral or injected ketorolac but still present.
How serious is the interaction between Ketorolac intranasal and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients with active bleeding or vitamin K-responsive coagulopathy; choose a non-NSAID analgesic.
What other medicines interact with Vitamin k1?
MediHelp also lists interactions of Vitamin k1 with, for example, Warfarin, Cholestyramine, Colestipol. The full list is on the Vitamin k1 page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
