相互作用
Vitamin k1 + Warfarin
重症度: 重大
Vitamin k1 and Warfarin: major interaction.
最終更新日
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概要
Vitamin K1 directly antagonizes warfarin and reduces INR, leading to loss of anticoagulation. This is used therapeutically for reversal but can cause unintended resistance with supplements.
この相互作用をわかりやすく説明すると
Vitamin k1 and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Vitamin k1 belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
なぜ起こるのか
Vitamin K1 restores synthesis of clotting factors II, VII, IX and X, opposing warfarin's inhibition of VKOR.
対処法
Keep vitamin K intake consistent and monitor INR whenever dosing changes; when used for reversal, titrate dose to INR and bleeding status.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Vitamin k1とWarfarinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Warfarinのその他の相互作用
Vitamin k1のその他の相互作用
よくある質問
Can I take Vitamin k1 with Warfarin?
MediHelp rates the interaction as major. Vitamin k1 and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin K1 directly antagonizes warfarin and reduces INR, leading to loss of anticoagulation. This is used therapeutically for reversal but can cause unintended resistance with supplements.
How serious is the interaction between Vitamin k1 and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep vitamin K intake consistent and monitor INR whenever dosing changes; when used for reversal, titrate dose to INR and bleeding status.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
