相互作用
Cholestyramine + Vitamin k1
重症度: 中等度
Cholestyramine and Vitamin k1: moderate interaction.
最終更新日
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概要
Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.
この相互作用をわかりやすく説明すると
Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Vitamin k1 belongs to Cardiovascular.
なぜ起こるのか
Cholestyramine binds bile acids and impairs micelle formation, reducing absorption of fat-soluble vitamin K.
対処法
Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CholestyramineとVitamin k1の臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cholestyramineのその他の相互作用
Vitamin k1のその他の相互作用
よくある質問
Can I take Cholestyramine with Vitamin k1?
MediHelp rates the interaction as moderate. Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.
How serious is the interaction between Cholestyramine and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
