相互作用
Linezolid + Naratriptan
重症度: 重大
Linezolid and Naratriptan: major interaction.
最終更新日
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概要
Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.
この相互作用をわかりやすく説明すると
Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Naratriptan belongs to Central Nervous System.
なぜ起こるのか
Additive serotonergic effect from MAO inhibition and 5-HT1B/1D agonism.
対処法
Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LinezolidとNaratriptanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Linezolidのその他の相互作用
Naratriptanのその他の相互作用
よくある質問
Can I take Linezolid with Naratriptan?
MediHelp rates the interaction as major. Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.
How serious is the interaction between Linezolid and Naratriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
