相互作用
Magnesium hydroxide + Raltegravir
重症度: 重大
Magnesium hydroxide and Raltegravir: major interaction.
最終更新日
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概要
Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
この相互作用をわかりやすく説明すると
Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Magnesium hydroxide belongs to Gastrointestinal Tract; Raltegravir belongs to Anti Virals.
なぜ起こるのか
Chelation of raltegravir by magnesium cations in the gastrointestinal tract reduces absorption.
対処法
Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Magnesium hydroxideとRaltegravirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Magnesium hydroxideのその他の相互作用
Raltegravirのその他の相互作用
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir 併用禁忌
- Aluminum hydroxide / magnesium carbonate + Raltegravir 重大
- Aluminum hydroxide / magnesium trisilicate + Raltegravir 重大
- Aluminum hydroxide + Raltegravir 重大
- Atidarsagene autotemcel + Raltegravir 重大
- Betibeglogene autotemcel + Raltegravir 重大
よくある質問
Can I take Magnesium hydroxide with Raltegravir?
MediHelp rates the interaction as major. Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
How serious is the interaction between Magnesium hydroxide and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
