相互作用
Palovarotene + Vitamin a
重症度: 重大
Palovarotene and Vitamin a: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Palovarotene is a retinoid, and vitamin A above the recommended daily intake adds to retinoid load. This increases the risk of hypervitaminis A toxicity, including liver injury, bone changes and raised intracranial pressure.
この相互作用をわかりやすく説明すると
Palovarotene and Vitamin a can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palovarotene belongs to Miscellaneous; Vitamin a belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive retinoid pharmacodynamic effects producing hypervitaminosis A.
対処法
Avoid vitamin A supplements above the recommended daily allowance during palovarotene treatment. Review multivitamin content and monitor for signs of retinoid toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PalovaroteneとVitamin aの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Vitamin aのその他の相互作用
Palovaroteneのその他の相互作用
よくある質問
Can I take Palovarotene with Vitamin a?
MediHelp rates the interaction as major. Palovarotene and Vitamin a can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is a retinoid, and vitamin A above the recommended daily intake adds to retinoid load. This increases the risk of hypervitaminis A toxicity, including liver injury, bone changes and raised intracranial pressure.
How serious is the interaction between Palovarotene and Vitamin a?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin A supplements above the recommended daily allowance during palovarotene treatment. Review multivitamin content and monitor for signs of retinoid toxicity.
What other medicines interact with Vitamin a?
MediHelp also lists interactions of Vitamin a with, for example, Acitretin, Etretinate, Isotretinoin. The full list is on the Vitamin a page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
