相互作用
Pexidartinib + Vitamin a
重症度: 中等度
Pexidartinib and Vitamin a: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Pexidartinib carries a serious hepatotoxicity risk, and high-dose vitamin A can also injure the liver. Concurrent use could add to liver injury, mainly with supplemental doses well above dietary intake.
この相互作用をわかりやすく説明すると
Pexidartinib and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pexidartinib belongs to Oncology; Vitamin a belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive hepatotoxicity.
対処法
Avoid high-dose vitamin A supplements during pexidartinib therapy. Monitor liver tests per pexidartinib labeling.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PexidartinibとVitamin aの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Vitamin aのその他の相互作用
Pexidartinibのその他の相互作用
よくある質問
Can I take Pexidartinib with Vitamin a?
MediHelp rates the interaction as moderate. Pexidartinib and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a serious hepatotoxicity risk, and high-dose vitamin A can also injure the liver. Concurrent use could add to liver injury, mainly with supplemental doses well above dietary intake.
How serious is the interaction between Pexidartinib and Vitamin a?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose vitamin A supplements during pexidartinib therapy. Monitor liver tests per pexidartinib labeling.
What other medicines interact with Vitamin a?
MediHelp also lists interactions of Vitamin a with, for example, Acitretin, Etretinate, Isotretinoin. The full list is on the Vitamin a page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
