Interações medicamentosas
Butorphanol + Sufentanil
Gravidade: Grave
Butorphanol and Sufentanil: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Butorphanol is a mixed agonist-antagonist, while sufentanil is a potent full mu-agonist. Together they can add to sedation and respiratory depression, and in opioid-dependent patients butorphanol may blunt analgesia or precipitate withdrawal. The effect depends on dose and prior opioid exposure.
O que esta interação significa em palavras simples
Butorphanol and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Butorphanol belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Por que acontece
Additive CNS depression plus partial mu-receptor antagonism by butorphanol competing with the full agonist.
O que fazer
Avoid concurrent use outside of carefully monitored anesthesia settings. Monitor ventilation, sedation and signs of withdrawal, and titrate doses conservatively.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicada
- Butorphanol + Sodium oxybate Contraindicada
- Alfentanil + Butorphanol Grave
- Alprazolam + Butorphanol Grave
- Alvimopan + Butorphanol Grave
- Amobarbital + Butorphanol Grave
Outras interações de Sufentanil
- Alprazolam + Sufentanil Grave
- Amitriptyline + Sufentanil Grave
- Amobarbital + Sufentanil Grave
- Aripiprazole + Sufentanil Grave
- Asenapine + Sufentanil Grave
- Baclofen + Sufentanil Grave
Perguntas frequentes
Can I take Butorphanol with Sufentanil?
MediHelp rates the interaction as major. Butorphanol and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Butorphanol is a mixed agonist-antagonist, while sufentanil is a potent full mu-agonist. Together they can add to sedation and respiratory depression, and in opioid-dependent patients butorphanol may blunt analgesia or precipitate withdrawal. The effect depends on dose and prior opioid exposure.
How serious is the interaction between Butorphanol and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use outside of carefully monitored anesthesia settings. Monitor ventilation, sedation and signs of withdrawal, and titrate doses conservatively.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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