Referência de medicamentos
Tetracycline
Tetracycline is a medicine in the class anti bacterial. It is used for acne.
- Classe do medicamento: Anti Bacterial
- Indicado para: acne
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O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Anti Bacterial
- Formas farmacêuticas comuns
- pomada, cápsula, spray, solução, injeção
- Concentrações comuns
- 250 mg, 30 mg/ml, 3%
- Interações conhecidas
- 108 (Contraindicada: 2 · Grave: 5 · Moderada: 72 · Leve: 29)
- Nomes comerciais
- 29
- Países e mercados
- 4
Para que é usado
Como funciona
Inhibits bacterial protein synthesis by binding with 30S and possibly 50S ribosomal subunit(s)
Dose habitual em adultos (resumo da bula)
Chronic Bronchitis, Acute Exacerbation (Usual daily dose): 500 mg PO q12hr or 250 mg PO q6hr (ie, 1000 mg/day)
Gravidez e amamentação
- Gravidez
- Unsafe Tetracyclines can permanently stain the baby's teeth and affect bone growth once tooth mineralisation starts (about 15-16 weeks), and high doses have caused serious liver toxicity in pregnant women. Avoid in pregnancy; use a safer antibiotic. Skin or eye use gives little absorption.
- Amamentação
- Safe Labels advise avoiding breastfeeding. LactMed is more reassuring: milk levels are low and milk calcium limits absorption, so short courses are probably acceptable; avoid prolonged or repeated courses. Watch the infant for rash, diarrhoea or thrush.
Efeitos adversos relatados
- Nausea
- Anorexia
- Hemolytic anemia
- Permanent discoloration of teeth
- Increased BUN (dose-related)
Contraindicações
- Documented hypersensitivity
- Severe hepatic dysfunction
- Pregnancy 2nd and 3rd trimesters
Quem deve ter cuidado
- Consider drug serum level determinations in prolonged therapy
- Antianabolic action of the tetracyclines may cause an increase in BUN; in patients with significantly impaired renal function.
- Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracyclines
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Principais interações (108)
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
- Tetracycline + Typhoid vaccine live Major
- Aluminum hydroxide + Tetracycline Moderate
- Aminolevulinic acid + Tetracycline Moderate
- Amoxicillin-clavulanic acid + Tetracycline Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Outros medicamentos desta classe
Perguntas frequentes
What is Tetracycline used for?
Tetracycline is a medicine in the class anti bacterial. It is used for Acne, Bronchitis, Brucellosis, Gonorrhea, Syphilis.
What side effects have been reported with Tetracycline?
Nausea, Anorexia, Hemolytic anemia, Permanent discoloration of teeth, Increased BUN (dose-related).
Can Tetracycline be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Tetracyclines can permanently stain the baby's teeth and affect bone growth once tooth mineralisation starts (about 15-16 weeks), and high doses have caused serious liver toxicity in pregnant women. Avoid in pregnancy; use a safer antibiotic. Skin or eye use gives little absorption. Breastfeeding: Safe. Labels advise avoiding breastfeeding. LactMed is more reassuring: milk levels are low and milk calcium limits absorption, so short courses are probably acceptable; avoid prolonged or repeated courses. Watch the infant for rash, diarrhoea or thrush.
What does Tetracycline interact with?
MediHelp lists 108 known interactions for Tetracycline. Contraindicated: 2 · Major: 5 · Moderate: 72 · Minor: 29. The most serious include Acitretin, Methoxyflurane, Isotretinoin.
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