Interações medicamentosas
Amikacin + Magnesium sulphate
Gravidade: Moderada
Amikacin and Magnesium sulphate: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
O que esta interação significa em palavras simples
Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
Por que acontece
Aminoglycoside tubular toxicity increases renal magnesium loss, and both agents impair neuromuscular transmission, producing additive effects.
O que fazer
Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Magnesium sulphate
Outras interações de Amikacin
- Amikacin + Cidofovir Contraindicada
- Adefovir + Amikacin Grave
- Amikacin + Amphotericin b Grave
- Amikacin + Amphotericin b deoxycholate Grave
- Amikacin + Atracurium Grave
- Amikacin + Bacitracin Grave
Perguntas frequentes
Can I take Amikacin with Magnesium sulphate?
MediHelp rates the interaction as moderate. Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
How serious is the interaction between Amikacin and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amphotericin b deoxycholate, Atracurium, Baloxavir marboxil. The full list is on the Magnesium sulphate page.
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