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Interações medicamentosas

Atracurium + Magnesium sulphate

Gravidade: Moderada

Atracurium and Magnesium sulphate: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.

O que esta interação significa em palavras simples

Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Atracurium belongs to Musculoskeletal; Magnesium sulphate belongs to Cardiovascular.

Nível de evidência: High

Por que acontece

Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity at the neuromuscular junction, adding to competitive blockade.

O que fazer

Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Atracurium with Magnesium sulphate?

MediHelp rates the interaction as moderate. Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.

How serious is the interaction between Atracurium and Magnesium sulphate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.

What other medicines interact with Magnesium sulphate?

MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Baloxavir marboxil. The full list is on the Magnesium sulphate page.

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