Interações medicamentosas
Amikacin + Vancomycin
Gravidade: Grave
Amikacin and Vancomycin: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both drugs can injure the kidneys, and amikacin also damages the inner ear. Used together they carry a higher rate of acute kidney injury than either alone, and renal decline further raises aminoglycoside levels and ototoxicity risk.
O que esta interação significa em palavras simples
Amikacin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
Por que acontece
Additive nephrotoxicity from proximal tubular injury, with reduced clearance increasing aminoglycoside exposure.
O que fazer
Avoid the combination where alternatives exist; otherwise monitor serum creatinine frequently and use therapeutic drug monitoring of both drugs. Dose to renal function and consider audiology monitoring for prolonged courses.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Vancomycin
- Bacitracin + Vancomycin Grave
- Capreomycin + Vancomycin Grave
- Cephaloridine + Vancomycin Grave
- Cidofovir + Vancomycin Grave
- Cisplatin + Vancomycin Grave
- Colistin + Vancomycin Grave
Outras interações de Amikacin
- Amikacin + Cidofovir Contraindicada
- Adefovir + Amikacin Grave
- Amikacin + Amphotericin b Grave
- Amikacin + Amphotericin b deoxycholate Grave
- Amikacin + Atracurium Grave
- Amikacin + Bacitracin Grave
Perguntas frequentes
Can I take Amikacin with Vancomycin?
MediHelp rates the interaction as major. Amikacin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidneys, and amikacin also damages the inner ear. Used together they carry a higher rate of acute kidney injury than either alone, and renal decline further raises aminoglycoside levels and ototoxicity risk.
How serious is the interaction between Amikacin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where alternatives exist; otherwise monitor serum creatinine frequently and use therapeutic drug monitoring of both drugs. Dose to renal function and consider audiology monitoring for prolonged courses.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Bacitracin, Capreomycin, Cephaloridine. The full list is on the Vancomycin page.
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