Interações medicamentosas
Cisplatin + Vancomycin
Gravidade: Grave
Cisplatin and Vancomycin: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.
O que esta interação significa em palavras simples
Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Vancomycin belongs to Anti Bacterial.
Por que acontece
Additive proximal tubular toxicity, with reduced renal clearance increasing exposure to both drugs.
O que fazer
Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Cisplatin e Vancomycin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Vancomycin
- Amikacin + Vancomycin Grave
- Bacitracin + Vancomycin Grave
- Capreomycin + Vancomycin Grave
- Cephaloridine + Vancomycin Grave
- Cidofovir + Vancomycin Grave
- Colistin + Vancomycin Grave
Outras interações de Cisplatin
- Cidofovir + Cisplatin Contraindicada
- Adefovir + Cisplatin Grave
- Adenovirus types 4 and 7 live + Cisplatin Grave
- Amikacin + Cisplatin Grave
- Amphotericin b deoxycholate + Cisplatin Grave
- Amphotericin b + Cisplatin Grave
Perguntas frequentes
Can I take Cisplatin with Vancomycin?
MediHelp rates the interaction as major. Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.
How serious is the interaction between Cisplatin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
