Interações medicamentosas
Amitriptyline + Dexchlorpheniramine
Gravidade: Moderada
Amitriptyline and Dexchlorpheniramine: moderate interaction.
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Resumo
Dexchlorpheniramine is a first-generation antihistamine with sedative and anticholinergic properties like amitriptyline. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
O que esta interação significa em palavras simples
Amitriptyline and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Por que acontece
Additive CNS depression and antimuscarinic effects.
O que fazer
Monitor for sedation and anticholinergic effects, especially in older patients. Switch to a non-sedating antihistamine if appropriate.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderada
- Amisulpride + Dexchlorpheniramine Moderada
- Amobarbital + Dexchlorpheniramine Moderada
- Asenapine + Dexchlorpheniramine Moderada
- Azelastine-fluticasone + Dexchlorpheniramine Moderada
- Azelastine + Dexchlorpheniramine Moderada
Perguntas frequentes
Can I take Amitriptyline with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Amitriptyline and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a first-generation antihistamine with sedative and anticholinergic properties like amitriptyline. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
How serious is the interaction between Amitriptyline and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, especially in older patients. Switch to a non-sedating antihistamine if appropriate.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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