Interações medicamentosas
Asenapine + Dexchlorpheniramine
Gravidade: Moderada
Asenapine and Dexchlorpheniramine: moderate interaction.
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Resumo
Combining asenapine with this sedating antihistamine can cause additive drowsiness and impaired psychomotor performance. Additive anticholinergic effects such as dry mouth and constipation may occur.
O que esta interação significa em palavras simples
Asenapine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Por que acontece
Additive CNS depression via H1 antagonism from both drugs, with additive antimuscarinic effects.
O que fazer
Warn patients about sedation and avoid driving until response is known. Prefer a non-sedating antihistamine where possible.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Asenapine
- Asenapine + Pimozide Contraindicada
- Asenapine + Thioridazine Contraindicada
- Asenapine + Vandetanib Contraindicada
- Adagrasib + Asenapine Grave
- Alfentanil + Asenapine Grave
- Alfuzosin + Asenapine Grave
Outras interações de Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderada
- Amisulpride + Dexchlorpheniramine Moderada
- Amitriptyline + Dexchlorpheniramine Moderada
- Amobarbital + Dexchlorpheniramine Moderada
- Azelastine-fluticasone + Dexchlorpheniramine Moderada
- Azelastine + Dexchlorpheniramine Moderada
Perguntas frequentes
Can I take Asenapine with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Asenapine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining asenapine with this sedating antihistamine can cause additive drowsiness and impaired psychomotor performance. Additive anticholinergic effects such as dry mouth and constipation may occur.
How serious is the interaction between Asenapine and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving until response is known. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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