Interações medicamentosas
Avanafil + Isosorbide dinitrate
Gravidade: Contraindicada
Avanafil and Isosorbide dinitrate: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both avanafil and isosorbide dinitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
O que esta interação significa em palavras simples
Avanafil and Isosorbide dinitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Isosorbide dinitrate belongs to Cardiovascular.
Por que acontece
PDE5 inhibition potentiates NO/cGMP vasodilation
O que fazer
Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Avanafil e Isosorbide dinitrate, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Avanafil
- Amyl nitrite + Avanafil Contraindicada
- Atazanavir + Avanafil Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Avanafil + Conivaptan Contraindicada
- Avanafil + Darunavir Contraindicada
- Avanafil + Fosamprenavir Contraindicada
Outras interações de Isosorbide dinitrate
- Isosorbide dinitrate + Riociguat Contraindicada
- Isosorbide dinitrate + Sildenafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Isosorbide dinitrate + Vardenafil Contraindicada
- Ergotamine + Isosorbide dinitrate Grave
- Isosorbide dinitrate + Methylergonovine Grave
Perguntas frequentes
Can I take Avanafil with Isosorbide dinitrate?
MediHelp rates the interaction as contraindicated. Avanafil and Isosorbide dinitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both avanafil and isosorbide dinitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
How serious is the interaction between Avanafil and Isosorbide dinitrate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
